2024
Editorial: The early life window of opportunity: role of the microbiome on immune system imprinting. Ardeshir A, Gensollen T, Zeng M, Al Nabhani Z, Blumberg R. Front Immunol. 2024 May 3;15:1417060. doi: 10.3389/fimmu.2024.1417060. eCollection 2024. PMID: 38765014
2023
Carlé C, Boucher D*, Morelli L*, Larue C, Ovtchinnikova E, Battut L, Boumessid K, Airaud M, Quaranta-Nicaise M, Ravanat JL, Dietrich G, Menard S, Eberl G, Barnich N, Mas E, Carriere M, Al Nabhani Z*, Barreau F*. Perinatal foodborne titanium dioxide exposure-mediated dysbiosis predisposes mice to develop colitis through life. Part Fibre Toxicol. 2023 Nov 23;20(1):45. doi: 10.1186/s12989-023-00555-5. PMID: 37996842
Toubon G, Butel MJ, Rozé JC, Lepage P, Delannoy J, Ancel PY, Charles MA, Aires J; EPIFLORE Study Group. Very Preterm Children Gut Microbiota Comparison at the Neonatal Period of 1 Month and 3.5 Years of Life. Front Microbiol. 2022 Jul 22;13:919317. doi: 10.3389/fmicb.2022.919317. eCollection 2022. PMID: 35935237
2020
Al Nabhani Z, Eberl G. Imprinting of the immune system by the microbiota early in life. Mucosal Immunol. 2020 Mar;13(2):183-189. doi: 10.1038/s41385-020-0257-y. Epub 2020 Jan 27. PMID: 31988466.
Al Nabhani Z, Berrebi D, Martinez-Vinson C, Montcuquet N, Madre C, Roy M, Ogier-Denis E, Dussaillant M, Cerf-Bensussan N, Zouali H, Daniel F, Barreau F, Hugot JP. Nod2 Protects the Gut From Experimental Colitis Spreading to Small Intestine. J Crohns Colitis. 2020 Jun 19;14(5):669-679. doi: 10.1093/ecco-jcc/jjz196. PMID: 31784737.
2019
Al Nabhani Z, Dulauroy S, Lécuyer E, Polomack B, Campagne P, Berard M, Eberl G. Excess calorie intake early in life increases susceptibility to colitis in adulthood. Nat Metab. 2019 Nov;1(11):1101-1109. doi: 10.1038/s42255-019-0129-5. Epub 2019 Nov 4. Erratum in: Nat Metab. 2019 Nov;1(11):1169. PMID: 32694861.
Al Nabhani Z, Dulauroy S, Marques R, Cousu C, Al Bounny S, Déjardin F, Sparwasser T, Bérard M, Cerf-Bensussan N, Eberl G. A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult. Immunity. 2019 May 21;50(5):1276-1288.e5. doi: 10.1016/j.immuni.2019.02.014. Epub 2019 Mar 19. PMID: 30902637.
2018 and older
Ferrand A, Al Nabhani Z, Tapias NS, Mas E, Hugot JP, Barreau F. NOD2 Expression in Intestinal Epithelial Cells Protects Toward the Development of Inflammation and Associated Carcinogenesis. Cell Mol Gastroenterol Hepatol. 2019;7(2):357-369. doi: 10.1016/j.jcmgh.2018.10.009. Epub 2018 Oct 23. PMID: 30704984; PMCID: PMC6357788.
Al Nabhani Z, Eberl G. GAPs in early life facilitate immune tolerance. Sci Immunol. 2017 Dec 15;2(18):eaar2465. doi: 10.1126/sciimmunol.aar2465. PMID: 29246947.
Rozé JC, Ancel PY, Lepage P, Martin-Marchand L, Al Nabhani Z, Delannoy J, Picaud JC, Lapillonne A, Aires J, Durox M, Darmaun D, Neu J, Butel MJ; Nutrition EPIPAGE 2 study group; EPIFLORE Study Group. Nutritional strategies and gut microbiota composition as risk factors for necrotizing enterocolitis in very-preterm infants. Am J Clin Nutr. 2017 Sep;106(3):821-830. doi: 10.3945/ajcn.117.152967. Epub 2017 Jun 28. PMID: 28659297; PMCID: PMC5573022.
Al Nabhani Z, Dietrich G, Hugot JP, Barreau F. Nod2: The intestinal gate keeper. PLoS Pathog. 2017 Mar 2;13(3):e1006177. doi: 10.1371/journal.ppat.1006177. PMID: 28253332; PMCID: PMC5333895.
Al Nabhani Z, Montcuquet N, Roy M, Dussaillant M, Hugot JP, Barreau F. Complementary Roles of Nod2 in Hematopoietic and Nonhematopoietic Cells in Preventing Gut Barrier Dysfunction Dependent on MLCK Activity. Inflamm Bowel Dis. 2017 Jul;23(7):1109-1119. doi: 10.1097/MIB.0000000000001135. PMID: 28520587.
Al Nabhani Z, Lepage P, Mauny P, Montcuquet N, Roy M, Le Roux K, Dussaillant M, Berrebi D, Hugot JP, Barreau F. Nod2 Deficiency Leads to a Specific and Transmissible Mucosa-associated Microbial Dysbiosis Which Is Independent of the Mucosal Barrier Defect. J Crohns Colitis. 2016 Dec;10(12):1428-1436. doi: 10.1093/ecco-jcc/jjw095. Epub 2016 May 4. PMID: 27147452.
Alnabhani Z, Hugot JP, Montcuquet N, Le Roux K, Dussaillant M, Roy M, Leclerc M, Cerf-Bensussan N, Lepage P, Barreau F. Respective Roles of Hematopoietic and Nonhematopoietic Nod2 on the Gut Microbiota and Mucosal Homeostasis. Inflamm Bowel Dis. 2016 Apr;22(4):763-73. doi: 10.1097/MIB.0000000000000749. PMID: 26963567.
Alnabhani Z, Montcuquet N, Biaggini K, Dussaillant M, Roy M, Ogier-Denis E, Madi A, Jallane A, Feuilloley M, Hugot JP, Connil N, Barreau F. Pseudomonas fluorescens alters the intestinal barrier function by modulating IL-1β expression through hematopoietic NOD2 signaling. Inflamm Bowel Dis. 2015 Mar;21(3):543-55. doi: 10.1097/MIB.0000000000000291. PMID: 25659087.
Madi A, Alnabhani Z, Leneveu C, Mijouin L, Feuilloley M, Connil N. Pseudomonas fluorescens can induce and divert the human β-defensin-2 secretion in intestinal epithelial cells to enhance its virulence. Arch Microbiol. 2013 Mar;195(3):189-95. doi: 10.1007/s00203-012-0865-3. Epub 2013 Jan 10. PMID: 23306900.
Jung C, Meinzer U, Montcuquet N, Thachil E, Château D, Thiébaut R, Roy M, Alnabhani Z, Berrebi D, Dussaillant M, Pedruzzi E, Thenet S, Cerf-Bensussan N, Hugot JP, Barreau F. Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling. J Clin Invest. 2012 Jun;122(6):2239-51. doi: 10.1172/JCI58147. Epub 2012 May 8. PMID: 22565313; PMCID: PMC3366397.
Meinzer U, Barreau F, Esmiol-Welterlin S, Jung C, Villard C, Léger T, Ben-Mkaddem S, Berrebi D, Dussaillant M, Alnabhani Z, Roy M, Bonacorsi S, Wolf-Watz H, Perroy J, Ollendorff V, Hugot JP. Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunction. Cell Host Microbe. 2012 Apr 19;11(4):337-51. doi: 10.1016/j.chom.2012.02.009. PMID: 22520462.
Mondot S, Barreau F, Al Nabhani Z, Dussaillant M, Le Roux K, Doré J, Leclerc M, Hugot JP, Lepage P. Altered gut microbiota composition in immune-impaired Nod2(-/-) mice. Gut. 2012 Apr;61(4):634-5. doi: 10.1136/gutjnl-2011-300478. Epub 2011 Aug 25. PMID: 21868489.
