2023
Seifritz T, Brunner M, Camarillo Retamosa E, Maciukiewicz M, Krošel M, Moser L, Züllig T, Tomšič M, Distler O, Ospelt C, Klein K. BRD3 Regulates the Inflammatory and Stress Response in Rheumatoid Arthritis Synovial Fibroblasts. Biomedicines. 2023; 11(12):3188. https://doi.org/10.3390/biomedicines11123188
Elhai M, Micheroli R, Houtman M, Mirrahimi M, Moser L, Pauli C, et al. The long non-coding RNA HOTAIR contributes to joint-specific gene expression in rheumatoid arthritis. Nat Commun. 2023;14(1):8172. https://doi.org/10.1038/s41467-023-44053-w
Krošel M, Moser L, Houtman M, Friščić J, Tomšič M, Distler O, Hoffmann MH, Ospelt C, and Klein K. Bromodomain Protein Inhibitors Reorganize the Chromatin of Synovial Fibroblasts. Cells. 2023;12(8). https://doi.org/10.3390/cells12081149
Krošel M, Gabathuler M, Moser L, Maciukiewicz M, Zullig T, Seifritz T, et al. The histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levels. Sci Rep. 2023;13(1):17112. https://doi.org/10.1038/s41598-023-44412-z
Friscic J, Reinwald C, Bottcher M, Houtman M, Euler M, Chen X, et al. Reset of Inflammatory Priming of Joint Tissue and Reduction of the Severity of Arthritis Flares by Bromodomain Inhibition. Arthritis Rheumatol. 2023;75(4):517-32.
https://doi.org/10.1002/art.42378
2022
Klein K (2022) The role of epigenetics in autoimmune disorders, in Handbook of Epigenetics, 3rd edition (Tollefsbol T ed), Elsevier.
2021
Ge X, Frank-Bertoncelj M, Klein K, McGovern A, Kuret T, Houtman M, et al. Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability. Genome Biol. 2021;22(1):247. https://doi.org/10.1186/s13059-021-02460-6
Krošel M, Gabathuler M, Maciukiewicz M, Moser L, Lee GI, Marks M, Tomsic, M., Distler, O., Ospelt, C., and Klein, K. Individual functions of the histone acetyl transferases CBP and p300 in regulating the inflammatory response of synovial fibroblasts. J Autoimmun. 2021;123:102709. https://doi.org/10.1016/j.jaut.2021.102709
Klein K (2021) Fibroblast in Sjögrens`s Syndrome, in Fibroblasts - Advances in Cancer, Autoimmunity and Inflammation (Frank-Bertoncel M ed), IntechOpen. https://doi.org/doi: 10.5772/intechopen.98946
Friscic J, Bottcher M, Reinwald C, Bruns H, Wirth B, Popp SJ, et al. The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts. Immunity. 2021;54(5):1002-21 e10. https://doi.org:10.1016/j.immuni.2021.03.003
