Publications

2023

The effect of duration of antimicrobial treatment for bacteremia in critically ill patients on in-hospital mortality - Retrospective double center analysis.

Zuercher P, Moser A, Frey MC, Pagani JL, Buetti N, Eggimann P, Daneman N, Fowler R, Que YA, Prazak J. J Crit Care. 2023 Apr;74:154257. doi: 10.1016/j.jcrc.2023.154257. Epub 2023 Jan 23. PMID: 36696827.

Efficacy of phage therapy in preclinical models of bacterial infection: a systematic review and meta-analysis.

Gómez-Ochoa SA, Pitton M, Valente LG, Sosa Vesga CD, Largo J, Quiroga-Centeno AC, Hernández Vargas JA, Trujillo-Cáceres SJ, Muka T, Cameron DR, Que YA. Lancet Microbe. 2022 Dec;3(12):e956-e968. doi: 10.1016/S2666-5247(22)00288-9. Epub 2022 Nov 10. PMID: 36370748.

Parallel Evolution of Pseudomonas aeruginosa during a Prolonged ICU-Infection Outbreak.

Cameron DR, Pitton M, Oberhaensli S, Schlegel K, Prod'hom G, Blanc DS, Jakob SM, Que YA. Microbiol Spectr. 2022 Nov 7:e0274322. doi: 10.1128/spectrum.02743-22. Epub ahead of print. PMID: 36342287.

Bacteriophages for the Treatment of Biofilm-Associated Infections.

Cameron, D.R., Valente, L.G., Pitton, M., Prazak, J., Que, YA. (2022). Richter, K., Kragh, K.N. (eds) Antibiofilm Strategies. Springer Series on Biofilms, vol 11. Springer, Cham. https://doi.org/10.1007/978-3-031-10992-8_8

Subtherapeutic Doses of Vancomycin Synergize with Bacteriophages for Treatment of Experimental Methicillin-Resistant Staphylococcus aureus Infective Endocarditis.

Save J, Que YA, Entenza J, Resch G. Viruses. 2022 Aug 16;14(8):1792. doi: 10.3390/v14081792. PMID: 36016414; PMCID: PMC9412893.

Mutation to ispA Produces Stable Small-Colony Variants of Pseudomonas aeruginosa That Have Enhanced Aminoglycoside Resistance.

Pitton M, Oberhaensli S, Appiah F, Pagani JL, Fournier A, Jakob SM, Que YA, Cameron DR. Antimicrob Agents Chemother. 2022 Jul 19;66(7):e0062122. doi: 10.1128/aac.00621-22. Epub 2022 Jul 5. PMID: 35852364; PMCID: PMC9295567.

Benefits of Aerosolized Phages for the Treatment of Pneumonia Due to Methicillin-Resistant Staphylococcus aureus: An Experimental Study in Rats.

Prazak J, Valente LG, Iten M, Federer L, Grandgirard D, Soto S, Resch G, Leib SL, Jakob SM, Haenggi M, Cameron DR, Que YA. J Infect Dis. 2022 Apr 19;225(8):1452-1459. doi: 10.1093/infdis/jiab112. PMID: 33668071; PMCID: PMC9016458.

Bacteriophages Combined With Subtherapeutic Doses of Flucloxacillin Act Synergistically against Staphylococcus aureus Experimental Infective Endocarditis.

Save J, Que YA, Entenza JM, Kolenda C, Laurent F, Resch G. J Am Heart Assoc. 2022 Feb;11(3):e023080. doi: 10.1161/JAHA.121.023080. Epub 2022 Jan 19. PMID: 35043655; PMCID: PMC9238497.

Accuracy of pancreatic stone protein for the diagnosis of infection in hospitalized adults: a systematic review and individual patient level meta-analysis.

Prazak J, Irincheeva I, Llewelyn MJ, Stolz D, García de Guadiana Romualdo L, Graf R, Reding T, Klein HJ, Eggimann P, Que YA. Crit Care. 2021 May 28;25(1):182. doi: 10.1186/s13054-021-03609-2. PMID: 34049579; PMCID: PMC8164316.

Progress and Pitfalls of Bacteriophage Therapy in Critical Care: A Concise Definitive Review.

Valente L, Prazak J, Que YA, Cameron DR. Crit Care Explor. 2021 Mar 8;3(3):e0351. doi: 10.1097/CCE.0000000000000351. PMID: 33786430; PMCID: PMC7994034.

Isolation and characterization of bacteriophages from the human skin microbiome that infect Staphylococcus epidermidis

Valente LG, Pitton M, Fürholz M, Oberhaensli S, Bruggman R, Leib S, Jakob SM, Resch G, Que Y-A, Cameron DR. , FEMS Microbes, Volume 2, 2021, xtab003, https://doi.org/10.1093/femsmc/xtab003

2022

B, Ott S, Piquilloud L, Prella M, Que YA, Soccal PM, von Garnier C, Geiser TK, Funke-Chambour M, Guler S. Frailty assessment for COVID-19 follow-up: a prospective cohort study. BMJ Open Respir Res. 2022. 9(1): e001227. PMID: 35459694.

2021

Prazak J, Irincheeva I, Llewelyn MJ, Stolz D, García de Guadiana Romualdo L, Graf R, Reding T, Klein HJ, Eggimann P, Que YA. Accuracy of pancreatic stone protein for the diagnosis of infection in hospitalized adults: a systematic review and individual patient level meta-analysis. Crit Care. 2021 May 28;25(1):182. doi: 10.1186/s13054-021-03609-2. PMID: 34049579; PMCID: PMC8164316.

Pugin J, Daix T, Pagani JL, Morri D, Giacomucci A, Dequin PF, Guitton C, Que YA, Zani G, Brealey D, Lepape A, Creagh-Brown B, Wyncoll D, Silengo D, Irincheeva I, Girard L, Rebeaud F, Maerki I, Eggimann P, François B. Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study. Crit Care. 2021 Apr 20;25(1):151. doi: 10.1186/s13054-021-03576-8. PMID: 33879189; PMCID: PMC8056692.

Muff S, Tabah A, Que YA, Timsit JF, Mermel L, Harbarth S, Buetti N. Short-Course Versus Long-Course Systemic Antibiotic Treatment for Uncomplicated Intravascular Catheter-Related Bloodstream Infections due to Gram-Negative Bacteria, Enterococci or Coagulase-Negative Staphylococci: A Systematic Review. Infect Dis Ther. 2021 Jun 25. doi: 10.1007/s40121-021-00464-0. Epub ahead of print. PMID: 34169480.

Valente L, Pitton M, Fürholz M, Oberhaensli S, Bruggmann R, Leib SL, Jakob SM, Resch G, Que YA, and Cameron DR. Isolation and characterisation of bacteriophages from the human skin microbiome that infect Staphylococcus epidermidis. FEMS Microbes. 2021. (in press)

Prazak J, Valente L, Iten M, Federer L, Grandgirard D, Soto S, Resch G, Leib SL, Jakob SM, Haenggi M, Cameron DR, Que YA. Benefits of aerosolized phages for the treatment of pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA): an experimental study in rats. J Infect Dis. 2021 Mar 1:jiab112. doi: 10.1093/infdis/jiab112. Epub ahead of print. PMID: 33668071.

Jeitziner MM, Jenni-Moser B, Yok-Ai Q, Thurnheer Zürcher MC, Furrer H, Jakob S. Importance of critical care staffing and standard intensive care therapy in the COVID-19 era: a descriptive study of the first epidemic wave at a Swiss tertiary intensive care unit. Swiss Med Wkly. 2021 Jun 25;151:w20529. doi: 10.4414/smw.2021.20529. PMID: 34233009.

Guler SA, Ebner L, Aubry-Beigelman C, Bridevaux PO, Brutsche M, Clarenbach C, Garzoni C, Geiser TK, Lenoir A, Mancinetti M, Naccini B, Ott SR, Piquilloud L, Prella M, Que YA, Soccal PM, von Garnier C, Funke-Chambour M. Pulmonary function and radiological features 4 months after COVID-19: first results from the national prospective observational Swiss COVID-19 lung study. Eur Respir J. 2021 Apr 29;57(4):2003690. doi: 10.1183/13993003.03690-2020. PMID: 33419891; PMCID: PMC8082329.

2020

Tsurumi A, Flaherty PJ, Que YA, Ryan CM, Mendoza AE, Almpani M, Bandyopadhaya A, Ogura A, Dhole YV, Goodfield LF, Tompkins RG, Rahme LG. Multi-Biomarker Prediction Models for Multiple Infection Episodes Following Blunt Trauma. iScience. 2020 Nov 20;23(11):101659. doi: 10.1016/j.isci.2020.101659. Epub 2020 Oct 7. PMID: 33047099; PMCID: PMC7539926.

Prazak J, Valente L, Iten M, Grandgirard D, Leib SL, Jakob SM, Haenggi M, Que YA, Cameron DR. Nebulized Bacteriophages for Prophylaxis of Experimental Ventilator-Associated Pneumonia Due to Methicillin-Resistant Staphylococcus aureus. Crit Care Med. 2020 Jul;48(7):1042-1046. doi: 10.1097/CCM.0000000000004352. PMID: 32304419.

Boschung-Pasquier L, Atkinson A, Kastner LK, Banholzer S, Haschke M, Buetti N, Furrer DI, Hauser C, Jent P, Que YA, Furrer H, Babouee Flury B. Cefepime neurotoxicity: thresholds and risk factors. A retrospective cohort study. Clin Microbiol Infect. 2020 Mar;26(3):333-339. doi: 10.1016/j.cmi.2019.06.028. Epub 2019 Jul 5. PMID: 31284030.

2019

Ogura A, Tsurumi A, Que YA, Almpani M, Zheng H, Tompkins RG, Ryan CM, Rahme LG. Associations between clinical characteristics and the development of multiple organ failure after severe burns in adult patients. Burns. 2019 Dec;45(8):1775-1782. doi: 10.1016/j.burns.2019.02.014. Epub 2019 Nov 2. PMID: 31690472.

Cameron DR, Ramette A, Prazak J, Entenza J, Haenggi M, Que YA, Resch G. Draft Genome Sequence of Methicillin-Resistant Staphylococcus aureus Strain AW7, Isolated from a Patient with Bacteremia. Microbiol Resour Announc. 2019 Oct 3;8(40):e00806-19. doi: 10.1128/MRA.00806-19. PMID: 31582437; PMCID: PMC6776766.

Prazak J, Iten M, Cameron DR, Save J, Grandgirard D, Resch G, Goepfert C, Leib SL, Takala J, Jakob SM, Que YA, Haenggi M. Bacteriophages Improve Outcomes in Experimental Staphylococcus aureus Ventilator-associated Pneumonia. Am J Respir Crit Care Med. 2019 Nov 1;200(9):1126-1133. doi: 10.1164/rccm.201812-2372OC. PMID: 31260638.

Leshkasheli L, Kutateladze M, Balarjishvili N, Bolkvadze D, Save J, Oechslin F, Que YA, Resch G. Efficacy of newly isolated and highly potent bacteriophages in a mouse model of extensively drug-resistant Acinetobacter baumannii bacteraemia. J Glob Antimicrob Resist. 2019 Dec;19:255-261. doi: 10.1016/j.jgar.2019.05.005. Epub 2019 May 14. PMID: 31100499.

Eggimann P, Pagani JL, Dupuis-Lozeron E, Ms BE, Thévenin MJ, Joseph C, Revelly JP, Que YA. Sustained reduction of catheter-associated bloodstream infections with enhancement of catheter bundle by chlorhexidine dressings over 11 years. Intensive Care Med. 2019 Jun;45(6):823-833. doi: 10.1007/s00134-019-05617-x. Epub 2019 Apr 17. PMID: 30997542; PMCID: PMC6534662.

Jault P, Leclerc T, Jennes S, Pirnay JP, Que YA, Resch G, Rousseau AF, Ravat F, Carsin H, Le Floch R, Schaal JV, Soler C, Fevre C, Arnaud I, Bretaudeau L, Gabard J. Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial. Lancet Infect Dis. 2019 Jan;19(1):35-45. doi: 10.1016/S1473-3099(18)30482-1. Epub 2018 Oct 3. PMID: 30292481.

Reviews

1. Valente, L, Prazak J, Que YA, Cameron DR. Progress and pitfalls of bacteriophage therapy in critical care: a concise definitive review. Critical Care Explorations. 3(3):e0351. 2021
2. Eggimann P, Que YA, Rebeaud F. Measurement of pancreatic stone protein in the identification and management of sepsis. Biomark Med. 13(2):135-145. 201

Letters to the Editor

1. Eggimann P, Pagani JL, Revelly JP, Que YA. Chlorhexidine-dress related contact dermatitis-the precautionary principle is no more relevant! Crit Care. Dec 9;24(1):687. 2020.

Book chapters

1. Moreillon P, Que YA. Staphylococcus aureus (including toxic shock syndrome). In: Principles and practice of infectious diseases. Mandell GL, Bennett JE, Dolin R. 9th Edition. 2020.